Mitral Loop LV Reshaping
The Mitral Loop LV Reshaping Loop — also known as MR Cerclage — is a device engineered to reshape the left ventricle (LV).
While it targets mitral regurgitation (MR), its therapeutic scope extends to broader
left ventricular dysfunction.
MTR Combo
MTR Combo is a transvenous therapy that reduces functional mitral regurgitation (MR) by reshaping the left ventricle through a loop around the mitral annulus. The system also integrates a tricuspid spacer, enabling treatment of combined MR and TR with a single device. Developed from NIH research with 19 human cases, the approach has since been applied in 5 additional cases by Tau Medical.
Pre-Implantation
Post-Implantation
Thru-Septal RF Ablation
Tau’s Thru-Septal RF Ablation system is a catheter-based device designed to access the ventricular septum via the venous system. It delivers targeted radiofrequency (RF) energy to ablate hypertrophied tissue associated with hypertrophic cardiomyopathy (HCM).
The TIRA catheter offers a simplified transvenous approach to septal reduction, addressing the limitations of surgical myectomy and trans-coronary alcohol septal ablation. It employs a low-profile ablation catheter delivered into the interventricular septum via the coronary sinus — following the same transvenous trajectory used in the through-septal technique.
In in vivo swine studies, intra-septal ablation was successfully achieved in all cases, resulting in localized regional wall motion abnormalities observed at follow-up. Our published study provides preclinical evidence supporting the feasibility, safety, and efficacy of this cerclage ablation method in reducing septal myocardial thickness.
The first human clinical trial has already been completed.
Thru-Septal Pacing
Tau’s Thru-Septal Pacing is a minimally invasive approach that enables direct access to the ventricular septum using a specialized pacemaker lead. This method allows for precise electrical stimulation of the heart’s conduction system, particularly targeting the His bundle and its surrounding region — the central axis of cardiac electrical signaling. By engaging this key area, Thru-Septal Pacing offers the potential for more physiological pacing and improved synchronization of ventricular contraction.
Target
Approach
HIS Pacing
HIS bundle & adjacent tissue
Thru-Septal Pacing
HIS bundle & adjacent tissue
Right atrium & ventricle
Coronary sinus & ventricular septal veins
Pacemaker Lead
Select Secure 3830 (Medtronic)
Any over-the-wire type lead (Medtronic, Boston, St Jude et al.)
Clinical Data
Obtained
Obtaining initial clinical data
1. In 10-20% of patients, it is difficult to locate the lead by finding the appropriate point.
2. The high Pacing output causes shortening of the life of the pacemaker battery.
1. General surgeons need education on the procedure as it is a new treatment approach.
2. In addition to the pacemaker’s general device tools, accessory devices necessary for the procedure are required (developed by Tau)
3. The procedure is affected by the septal vein structure.ndle & adjacent tissue
Advantages
(Pros)
Alternative to pacemaker and ventricular synchronization therapy
Provides wider treatment opportunities as an alternative to other approaches for HIS pacing