Septal Reduction Using Transvenous Intramyocardial Cerclage Radiofrequency Ablation: Preclinical Feasibility
JACC 2020
by Eun-Seok Shin et al.
Abstract
Debulking of left ventricular septal mass is typically accomplished using surgical myectomy, which is morbid, or using transcoronary alcohol septal ablation, which can result in geographic miss and occasional catastrophic nontarget coronary injury. The authors developed and tested operational parameters in vitro and vivo for a device to accomplish transvenous intraseptal radiofrequency ablation to reduce ventricular septal mass using a technique derived from mitral cerclage, which the authors call cerclage ablation. Cerclage ablation appeared feasible in vitro and safe and effective in vivo. Cerclage ablation is an attractive new approach to debulk the interventricular septum in obstructive hypertrophic cardiomyopathy. These data support clinical investigation.
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author
Eun-Seok Shin, Min-Ku Chon, Eun Jung Jun, Yong-Hyun Park, Sang-Hyun Lee,
Jeong-Su Kim, Dong-Hun Shin, Soo-Yong Lee, Min Soo Cho, Seung-Whan Lee,
Markus Reinthaler, Jai-Wun Park, Gi-Byung Nam, Robert J. Lederman,
Yonghyun Won, June-Hong Kim
Keywords
AV, atrioventricular; CT, computed tomography; HCM, hypertrophic cardiomyopathy; RF, radiofrequency; TTE, transthoracic echocardiography; echocardiography; hypertrophic cardiomyopathy; mitral cerclage; radiofrequency ablation; ventricular septum.